Ensaio clínico randomizado controlado para avaliar o tratamento para a reconstrução do rebordo alveolar atrofiado utilizando Bloco de Osso Xenogênico Colagenado (BOCX) em comparação com o tratamento de Bloco Ósseo Autógeno (BOA) / Randomized controlled clinical trial to evaluate the treatment of atrophied alveolar ridge reconstruction using Collaged Xenogenic Bone Block (CXBB) versus Autogenous Bone Block (ABB) treatment

Comparar a segurança e o desempenho através da análise tomográfica do Bloco de Osso Xenogênico Colagenado (BOXC) para reconstrução horizontal do rebordo alveolar atrofiado, em áreas de um a quatro dentes de extensão, comparado com o enxerto em Bloco de Osso Autógeno (BOA), padrão ouro em reabilitações para esse tipo de defeito. Material e Método: Sessenta e quatro pacientes foram selecionados e randomizados aleatoriamente nos grupos BOXC e BOA, ambos associados com Mineral de Osso Bovino Desproteinizado (MOBD) recobertos com uma Membrana de Colágeno (MC), para o aumento ósseo horizontal. Medidas tomográficas prévias ao enxerto (BL) e após 30 semanas (FU) foram realizadas através da sobreposição dos arquivos tomográficos. O desfecho primário foi a largura da crista óssea horizontal a 2 mm abaixo da crista óssea alveolar vestibular (HCB-2). As medidas também incluíram alterações, vestibular e palatina, a 2mm, 4mm, 6mm, 8mm e 10mm abaixo da crista óssea. Resultados: Após 30 semanas, as alterações estimadas de ganho de espessura vestibular, na região central do sítio alvo a 2mm, 4mm, 6mm, 8mm e 10mm abaixo da crista óssea alveolar, foram, respectivamente, de: 3,71(±1,55), 4,58(±1,11),4,30(±1,05), 3,38(±1,28) e 2,05(±1,59), para o BOA e 3,23(±2,11), 4,29(±1,27), 4,43(±1,08), 4,11(±1,60) e 2,85(±2,13) para BOXC, sem diferença estatística entre os grupos para HCB-2. Conclusão: O BOXC pode ser usado para tratamentos de enxerto ósseo de ganho horizontal em superfície vestibular, pois apresentou resultados semelhantes quando comparado ao padrão ouro (BOA).

Clinical outcomes following atrophic alveolar ridge reconstruction using collagenated xenogeneic bone block or autogenous bone block: One-year follow-up of a randomized controlled clinical.

AIM: This investigation aimed to evaluate the 1-year survival of implants placed after staged lateral alveolar ridge augmentation using equine-derived collagenated xenogeneic bone blocks (CXBBs) or autogenous bone block (ABB). MATERIALS AND METHODS: Fifty patients who underwent lateral augmentation in a previous trial were included. The primary outcome measure was implant survival at the 1-year follow-up, and secondary outcomes included implant success, peri-implant clinical and volumetric parameters, pink aesthetic scores (PES) and patient-reported outcome measures. Data analysis involved Fisher's exact test, the Mann-Whitney U-test and the Wilcoxon signed-rank test. RESULTS: In this study, no late implant failures were observed. The cumulative survival rates were 78.6% for the CXBB group and 90.9% for the ABB group, with no difference between the groups. Similarly, the success rates were 53.6% and 63.6%, respectively, showing no significant difference. Peri-implant clinical and volumetric parameters indicated the presence of healthy peri-implant tissues surrounding implants placed in both CXBB- and ABB-augmented sites. PES were 8.5 and 11.0 for implants placed in CXBB- and ABB-augmented sites, respectively. Furthermore, patient satisfaction rates were high and similar between the groups. CONCLUSIONS: Dental implants placed in both CXBB- and ABB-augmented ridges demonstrated no statistically significant differences in clinical, volumetric and aesthetic outcomes, along with high patient satisfaction rates.

Radiographic outcomes of ridge reconstruction with autogenous bone block versus collagenated xenogeneic bone block: A randomized clinical trial.

AIM: To compare, at different levels from the alveolar crest, the radiographic outcomes of equine-derived collagenated xenogeneic bone blocks (CXBB) and autogenous bone blocks (ABB) used for lateral alveolar ridge augmentation. MATERIALS AND METHODS: Sixty-four patients with tooth gaps in atrophic alveolar ridges with ≤4 mm were randomly assigned to lateral augmentation using CXBB or ABB. The lateral bone thickness (LBT) was measured 2, 4, 6, 8, and 10 mm below the alveolar crest using CBCT scans obtained before augmentation surgery and at 30 weeks, prior to implant placement. Statistical analysis was performed using Shapiro-Wilk, Fisher's exact, Mann-Whitney, and Wilcoxon signed-rank tests. RESULTS: Both CXBB and ABB resulted in significant total and buccal LBT gains at 2, 4, 6, 8, and 10 mm. LBT gains were similar between CXBB- and ABB-augmented sites, except for greater buccal LBT gains at 8 mm at CXBB-augmented sites. While ABB-augmented sites gained vertical bone height, CXBB-treated sites suffered vertical bone loss (CXBB: -0.16 mm; ABB: 0.38 mm, p < .0009). CONCLUSIONS: CXBB and ABB were both associated with significant and similar LBT gains at 30 weeks.

Autogenous bone block versus collagenated xenogeneic bone block in the reconstruction of the atrophic alveolar ridge: A non-inferiority randomized clinical trial.

AIM: To compare the efficacy of equine-derived collagenated xenogeneic bone blocks (CXBB) and autogenous bone block (ABB) for lateral alveolar ridge augmentation and two-stage implant placement. MATERIALS AND METHODS: Sixty-four patients with tooth gaps up to four teeth and atrophic alveolar ridges with ≤4 mm were randomly assigned to lateral augmentation using CXBB or ABB. Lateral bone thickness (LBT) was measured 2 mm below the alveolar crest at augmentation surgery and 30 weeks later at implant placement. Implant-related outcomes, adverse events, surgery duration, pain sensation, analgesic consumption, and oral health-related quality of life were also assessed. Data were analysed using Fisher's exact, Mann-Whitney, and Wilcoxon signed-rank tests. RESULTS: At 30 weeks, the median change in LBT amounted to 2.90 (CXBB) and 3.00 (ABB), respectively. Secondary endpoints demonstrated similar results for CXBB and ABB in terms of possibility to place an implant, need to perform a secondary bone augmentation at implant placement and rate of complications. Early implant failure was 20% for CXBB and 10% for ABB, with no difference between the groups. Pain scores and post-operative consumption of analgesics were significantly lower in the CXBB group than in the ABB group, especially during the first days post-surgery. CONCLUSIONS: CXBB is non-inferior to ABB for horizontal alveolar ridge augmentation and two-stage implant placement.

Ensaio clínico randomizado controlado para avaliar o tratamento para a reconstrução do rebordo alveolar atrofiado utilizando Bloco de Osso Xenogênico Colagenado (BOCX) em comparação com o tratamento de Bloco Ósseo Autógeno (BOA) / Randomized controlled clinical trial to evaluate the treatment of atrophied alveolar ridge reconstruction using Collaged Xenogenic Bone Block (CXBB) versus Autogenous Bone Block (ABB) treatment

Comparar a segurança e o desempenho através da análise tomográfica do Bloco de Osso Xenogênico Colagenado (BOXC) para reconstrução horizontal do rebordo alveolar atrofiado, em áreas de um a quatro dentes de extensão, comparado com o enxerto em Bloco de Osso Autógeno (BOA), padrão ouro em reabilitações para esse tipo de defeito. Material e Método: Sessenta e quatro pacientes foram selecionados e randomizados aleatoriamente nos grupos BOXC e BOA, ambos associados com Mineral de Osso Bovino Desproteinizado (MOBD) recobertos com uma Membrana de Colágeno (MC), para o aumento ósseo horizontal. Medidas tomográficas prévias ao enxerto (BL) e após 30 semanas (FU) foram realizadas através da sobreposição dos arquivos tomográficos. O desfecho primário foi a largura da crista óssea horizontal a 2 mm abaixo da crista óssea alveolar vestibular (HCB-2). As medidas também incluíram alterações, vestibular e palatina, a 2mm, 4mm, 6mm, 8mm e 10mm abaixo da crista óssea. Resultados: Após 30 semanas, as alterações estimadas de ganho de espessura vestibular, na região central do sítio alvo a 2mm, 4mm, 6mm, 8mm e 10mm abaixo da crista óssea alveolar, foram, respectivamente, de: 3,71(±1,55), 4,58(±1,11),4,30(±1,05), 3,38(±1,28) e 2,05(±1,59), para o BOA e 3,23(±2,11), 4,29(±1,27), 4,43(±1,08), 4,11(±1,60) e 2,85(±2,13) para BOXC, sem diferença estatística entre os grupos para HCB-2. Conclusão: O BOXC pode ser usado para tratamentos de enxerto ósseo de ganho horizontal em superfície vestibular, pois apresentou resultados semelhantes quando comparado ao padrão ouro (BOA).